MED29

MED29
Identifiers
Aliases	MED29, IXL, MED2, mediator complex subunit 29
External IDs	OMIM: 612914; MGI: 1914474; GeneCards: MED29
Gene location (Human)
Chr.	Chromosome 19 (human)
End	39,400,641 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	28,092,133 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; amygdala; ; cingulate gyrus; ; anterior cingulate cortex; ; putamen; ; nucleus accumbens; ; caudate nucleus; ; hypothalamus; ; C1 segment; ; muscle of thigh;
	Top expressed in
	interventricular septum; ; lumbar spinal ganglion; ; morula; ; yolk sac; ; seminiferous tubule; ; embryo; ; embryo; ; right kidney; ; otic placode; ; epiblast;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	mediator complex; nucleus; nucleoplasm;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55588
	67224
	ENSG00000063322
	ENSMUSG00000003444
	Q9NX70
	Q9DB91
	NM_017592; NM_001317770
	NM_026042
	NP_001304699; NP_060062
	NP_080318
	Wikidata
View/Edit Human	View/Edit Mouse

Mediator of RNA polymerase II transcription subunit 29 (Med29) is a transcription suppressor that in humans is encoded by the MED29 gene.^[5] It represents subunit MED29 of the Mediator complex.

Med29, along with Med11 and Med28 in mammals, is part of the core head-region of the Mediator complex. Med29 is the apparent orthologue of the Drosophila melanogaster Intersex protein (IXL), which interacts directly with, and functions as a transcriptional coactivator for, the DNA-binding transcription factor Doublesex, so it is likely that mammalian Med29 serves as a target for one or more DNA-binding transcriptional activators.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000063322 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003444 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang Y, Li Y, Zeng W, Zhu C, Xiao J, Yuan W, et al. (2004). "IXL, a new subunit of the mammalian Mediator complex, functions as a transcriptional suppressor". Biochem Biophys Res Commun. 325 (4): 1330–8. doi:10.1016/j.bbrc.2004.10.159. PMID 15555573.
^ Conaway RC, Sato S, Tomomori-Sato C, Yao T, Conaway JW (May 2005). "The mammalian Mediator complex and its role in transcriptional regulation". Trends Biochem. Sci. 30 (5): 250–5. doi:10.1016/j.tibs.2005.03.002. PMID 15896743.

This article incorporates text from the public domain Pfam and InterPro: IPR021018