Protein-coding gene in humans
Cell death-inducing DFFA-like effector b , also known as CIDEB gene .[ 5] [ 6] [ 7]
In humans, individuals carrying rare loss of function mutations in the CIDEB gene are protected against different aetiologies of liver disease.[ 8] knockout mice have been generated by homolog recombination technique. The CIDE null mice show decreased lipogenesis . The CIDEB knockout mice are resistant to high fat diet induced obesity and liver steatosis . In addition, the CIDEB null mice also have improved insulin sensitivity and enhanced hepatic fatty acid oxidation and whole body metabolism.[ 9] in vitro results in fat accumulation by inducing larger lipid droplets, while CIDEB knock-out experiments results in accumulation of smaller lipid droplets.[ 10] [ 8]
References
^ a b c ENSG00000285199 GRCh38: Ensembl release 89: ENSG00000136305, ENSG00000285199 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022219 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: CIDEB cell death-inducing DFFA-like effector b" .^ Ye J, Li JZ, Liu Y, Li X, Yang T, Ma X, et al. (February 2009). "Cideb, an ER- and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B" . Cell Metabolism . 9 (2): 177– 190. doi :10.1016/j.cmet.2008.12.013 PMID 19187774 . ^ Li JZ, Lei Y, Wang Y, Zhang Y, Ye J, Xia X, et al. (May 2010). "Control of cholesterol biosynthesis, uptake and storage in hepatocytes by Cideb". Biochimica et Biophysica Acta . 1801 (5): 577– 586. doi :10.1016/j.bbalip.2010.01.012 . PMID 20123130 . ^ a b Verweij N, Haas ME, Nielsen JB, Sosina OA, Kim M, Akbari P, et al. (July 2022). "Germline Mutations in CIDEB and Protection against Liver Disease" . The New England Journal of Medicine . 387 (4): 332– 344. doi :10.1056/NEJMoa2117872 PMID 35939579 . S2CID 251143047 . ^ Li JZ, Ye J, Xue B, Qi J, Zhang J, Zhou Z, et al. (October 2007). "Cideb regulates diet-induced obesity, liver steatosis, and insulin sensitivity by controlling lipogenesis and fatty acid oxidation" . Diabetes . 56 (10): 2523– 2532. doi :10.2337/db07-0040 PMID 17646209 . ^ Xu W, Wu L, Yu M, Chen FJ, Arshad M, Xia X, et al. (February 2016). "Differential Roles of Cell Death-inducing DNA Fragmentation Factor-α-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes" . The Journal of Biological Chemistry . 291 (9): 4282– 4293. doi :10.1074/jbc.M115.701094 PMC 4813457 PMID 26733203 .
Further reading
Inohara N, Koseki T, Chen S, Wu X, Núñez G (May 1998). "CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor" . The EMBO Journal . 17 (9): 2526– 2533. doi :10.1093/emboj/17.9.2526 . PMC 1170594 PMID 9564035 . Lugovskoy AA, Zhou P, Chou JJ, McCarty JS, Li P, Wagner G (December 1999). "Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis" . Cell . 99 (7): 747– 755. doi :10.1016/S0092-8674(00)81672-4 PMID 10619428 . Chen Z, Guo K, Toh SY, Zhou Z, Li P (July 2000). "Mitochondria localization and dimerization are required for CIDE-B to induce apoptosis" . The Journal of Biological Chemistry . 275 (30): 22619– 22622. doi :10.1074/jbc.C000207200 PMID 10837461 . Liang L, Zhao M, Xu Z, Yokoyama KK, Li T (February 2003). "Molecular cloning and characterization of CIDE-3, a novel member of the cell-death-inducing DNA-fragmentation-factor (DFF45)-like effector family" . The Biochemical Journal . 370 (Pt 1): 195– 203. doi :10.1042/BJ20020656 . PMC 1223158 PMID 12429024 . Erdtmann L, Franck N, Lerat H, Le Seyec J, Gilot D, Cannie I, et al. (May 2003). "The hepatitis C virus NS2 protein is an inhibitor of CIDE-B-induced apoptosis" . The Journal of Biological Chemistry . 278 (20): 18256– 18264. doi :10.1074/jbc.M209732200 PMID 12595532 . Da L, Li D, Yokoyama KK, Li T, Zhao M (February 2006). "Dual promoters control the cell-specific expression of the human cell death-inducing DFF45-like effector B gene" . The Biochemical Journal . 393 (Pt 3): 779– 788. doi :10.1042/BJ20051027 . PMC 1360731 PMID 16248853 .
