Protein found in humans
Mitogen-activated protein kinase kinase kinase 6 is a protein that in humans is encoded by the MAP3K6 gene .[ 5]
Function
This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
References
Further reading
Takeda K, Shimozono R, Noguchi T, Umeda T, Morimoto Y, Naguro I, Tobiume K, Saitoh M, Matsuzawa A, Ichijo H (March 2007). "Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1" . J. Biol. Chem . 282 (10): 7522– 31. doi :10.1074/jbc.M607177200 PMID 17210579 . Arning L, Monté D, Hansen W, Wieczorek S, Jagiello P, Akkad DA, Andrich J, Kraus PH, Saft C, Epplen JT (April 2008). "ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease". J. Mol. Med . 86 (4): 485– 90. doi :10.1007/s00109-007-0299-6 . PMID 18327563 . S2CID 9535075 . Eto N, Miyagishi M, Inagi R, Fujita T, Nangaku M (April 2009). "Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression" . Am. J. Pathol . 174 (4): 1553– 63. doi :10.2353/ajpath.2009.080190 . PMC 2671385 PMID 19246638 . Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip" . Am. J. Hum. Genet . 85 (5): 628– 42. doi :10.1016/j.ajhg.2009.10.014 . PMC 2775832 PMID 19913121 . Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (October 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study" . Diabetes Care . 33 (10): 2250– 3. doi :10.2337/dc10-0452 . PMC 2945168 PMID 20628086 . Gaston D, Hansford S, Oliveira C, Nightingale M, Pinheiro H, Macgillivray C, Kaurah P, Rideout AL, Steele P, Soares G, Huang WY, Whitehouse S, Blowers S, LeBlanc MA, Jiang H, Greer W, Samuels ME, Orr A, Fernandez CV, Majewski J, Ludman M, Dyack S, Penney LS, McMaster CR, Huntsman D, Bedard K (October 2014). "Germline mutations in MAP3K6 are associated with familial gastric cancer" . PLOS Genet . 10 (10) e1004669. doi :10.1371/journal.pgen.1004669 PMC 4207611 PMID 25340522 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
