Protein-coding gene in the species Homo sapiens
APAF1-interacting protein is a protein that in humans is encoded by the APIP gene .[ 5] [ 6] [ 7] Methylthioribulose 1-phosphate dehydratase activity[ 8] [ 9] methionine salvage pathway.
APIP deficiency is associated with cell death [ 10]
Interactions
APIP has been shown to interact with APAF1 .[ 6]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000149089 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000010911 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (August 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics" . Genome Research . 10 (5): 703– 713. doi :10.1101/gr.10.5.703 . PMC 310876 PMID 10810093 . ^ a b Cho DH, Hong YM, Lee HJ, Woo HN, Pyo JO, Mak TW, et al. (September 2004). "Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein" . The Journal of Biological Chemistry . 279 (38): 39942– 39950. doi :10.1074/jbc.M405747200 PMID 15262985 . ^ "Entrez Gene: APIP APAF1 interacting protein" .^ Mary C, Duek P, Salleron L, Tienz P, Bumann D, Bairoch A, et al. (2012). Di Cunto F (ed.). "Functional Identification of APIP as Human mtnB, a Key Enzyme in the Methionine Salvage Pathway" . PLOS ONE . 7 (12) e52877. Bibcode :2012PLoSO...752877M . doi :10.1371/journal.pone.0052877 PMC 3532061 PMID 23285211 . ^ Kang W, Hong SH, Lee HM, Kim NY, Lim YC, Le Le TM, et al. (January 2014). "Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme" . Proceedings of the National Academy of Sciences of the United States of America . 111 (1): E54–61. Bibcode :2014PNAS..111E..54K . doi :10.1073/pnas.1308768111 PMC 3890807 PMID 24367089 . ^ Ko DC, Gamazon ER, Shukla KP, Pfuetzner RA, Whittington D, Holden TD, et al. (2012). "Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death" . Proceedings of the National Academy of Sciences of the United States of America . 109 (35): E2343– E2352. doi :10.1073/pnas.1206701109 PMC 3435171 PMID 22837397 .
External links
Further reading
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Research . 16 (1): 55– 65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173– 1178. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology . 6 (2): 97– 105. doi :10.1038/ncb1086 . PMID 14743216 . S2CID 11683986 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1– 2): 149– 156. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1– 2): 171– 174. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 .
